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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL5
All Species:
4.24
Human Site:
S543
Identified Species:
11.67
UniProt:
O76039
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76039
NP_001032420.1
1030
115538
S543
S
D
T
R
T
L
L
S
P
S
G
R
N
N
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
NP_001129485
570
64691
F108
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
Dog
Lupus familis
XP_548881
960
107395
D494
K
S
H
G
A
L
S
D
S
K
S
V
S
N
L
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTQ8
938
105471
S476
Y
I
D
T
I
P
Q
S
S
R
S
P
S
Y
R
Rat
Rattus norvegicus
Q5XIT0
507
57117
K45
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514328
967
107039
S494
T
K
P
K
S
H
G
S
L
S
D
S
K
S
V
Chicken
Gallus gallus
XP_425571
960
107495
S495
S
H
G
V
L
T
D
S
K
S
V
G
N
L
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001124243
1039
116666
S567
H
S
P
S
G
R
G
S
N
R
L
E
G
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796071
627
72401
V79
R
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
26.7
88.1
N.A.
85.9
23.6
N.A.
76.5
75.2
N.A.
55.3
N.A.
N.A.
N.A.
N.A.
25.5
Protein Similarity:
100
N.A.
39.5
89.7
N.A.
88.9
36.5
N.A.
82.5
83.6
N.A.
69.1
N.A.
N.A.
N.A.
N.A.
39
P-Site Identity:
100
N.A.
6.6
13.3
N.A.
13.3
13.3
N.A.
13.3
26.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
13.3
20
N.A.
20
26.6
N.A.
40
26.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
0
0
0
0
0
12
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
23
23
12
0
0
12
12
0
0
12
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
12
0
12
12
12
0
% E
% Phe:
0
0
0
0
0
0
0
12
12
0
0
0
0
0
0
% F
% Gly:
0
0
23
12
12
0
23
0
0
0
12
12
23
12
12
% G
% His:
12
12
12
0
0
12
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
12
0
0
12
0
0
0
0
23
12
0
0
12
12
% I
% Lys:
12
12
0
23
23
0
0
12
23
12
0
0
12
12
0
% K
% Leu:
0
0
0
0
23
23
34
0
12
0
12
0
0
12
12
% L
% Met:
0
0
0
0
0
12
0
0
0
0
0
12
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
12
0
0
12
23
23
12
% N
% Pro:
0
0
23
0
0
12
0
0
12
0
0
12
0
0
0
% P
% Gln:
12
0
0
12
0
0
12
0
12
0
0
0
0
0
0
% Q
% Arg:
12
12
0
12
0
12
0
0
0
23
0
12
12
0
23
% R
% Ser:
34
23
0
12
12
0
12
56
23
34
23
12
23
12
12
% S
% Thr:
12
0
12
12
12
12
0
0
0
0
0
0
0
0
12
% T
% Val:
0
12
12
12
0
0
12
12
0
0
12
23
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
0
0
0
0
23
0
0
0
0
12
0
0
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _